Histology Course A III 40 Department of Pathology, University of Zurich Histology Course

A III 40 hemorrhagic infarction of the lung HE further information (German) on HiPaKu 
  ICD-10: I26
 
   
68-year-old male suffered from congestive heart disease due to aortic stenosis. He experienced a sudden stabbing chest pain. Examination of the lungs revealed a pleural friction rub. After an episode of acute severe dyspnea and hemoptysis, the patient passed away (specimen from autopsy).
 
- A wedge-shaped subpleural hemorrhagic (red) infarct is present.
- Within the hemorrhage, the outlines of the alveoli are still visible. However, the tissue has undergone coagulative necrosis and viable cells are lacking. Some of the debris has been already cleared.
- A dense infiltrate of neutrophilic granulocytes is observed within the infracted area, indicating presence of infarct pneumonia.
- A rim of fibrous tissue, capillary proliferations and inflammatory cells surround the infracted area (organization).
- Close to the apex of the infarct, a partially occluded vessel is observed. The occluding thrombembolus is partly organized. In addition, venules show medial thickening and intimal fibrosis (arterialization) because of chronic congestion.
- The pleura adjacent to an infarct is often covered by a fibrinous exudate (not present in the slide displayed).