Histology Course A III 38 Department of Pathology, University of Zurich Histology Course

A III 38 subacute intracerebral hemorrhage HE  
  ICD-10: I61
 
   
73-year-old male patient suffered from essential hypertension. He had acute intracerebral bleeding to which he succumbed after 36 hours (specimen from autopsy; see also slide A III 37).
 
- A section of the cortex is observed with an adjacent area of destroyed brain tissue. The latter region corresponds to an organized hemorrhage. At the periphery of the destroyed tissue, numerous lipid laden macrophages are observed. In addition, hemosiderin deposits are focally present.
- The center shows necrotic tissue and lysed erythrocytes.
- The brain tissue immediately adjacent to the hemorrhage exhibits a perifocal edema, marked by a spongy appearance of the tissue.

 
Macroscopy: The cerebral hemosphere is disrupted and distended by a hemorrhage. The hemorrhage has ruptured into the ventricular system.