Histology Course A III 35 Department of Pathology, University of Zurich Histology Course

A III 35 coronary artery sclerosis with superimposed thrombosis Orcein-Sirius further information (German) on HiPaKu 
  ICD-10: I70 I74
 
   
76-year-old male patient suffered from peripheral vascular disease with intermittent claudication. He succumbed to myocardial infarction (specimen from autopsy).
 
- Four sections of coronary arteries are shown, all exhibiting atheromatous plaques. A fibrous plaque is observed in the intima of the artery to the left. In the vicinity of the thickened intima the internal elastic layer of the media is destroyed and the media shows thinning. These changes of the media are observed in all the sections displayed.
- The top section to the right shows an artery exhibiting a pronounced stenosis. A fibrofatty plaque is present consisting of a large fibrous cap and a necrotic lipid core.
- The arteries in the middle and the bottom exhibit fibrofatty plaques. In addition, the lumen is nearly completely occluded by a partly organized thrombus. The latter shows some recanalization at the edges.

 
see as well following sample A III 36