Histology Course A III 33 Department of Pathology, University of Zurich Histology Course

A III 33 cerebral infarction stage II with perifocal and generalized edema HE  
  ICD-10: I63 G93.6
56-year-old female patient suffered from metastasized breast cancer. She had metastases in the brain and ultimately died of right ventricular failure (specimen from autopsy).
- The tissue section shows mostly white matter and a part of the cerebral cortex.
- In the middle of the section, staining of the tissue is distinctly less intense. This region corresponds to a cerebral infarct, stage II. At the border, the infarct shows an edema, marked by a spongy appearance of the white matter.
- Within the infarct, the matrix is scant and edematous. Macrophages exhibiting a foamy cytoplasm are present within the necrotic area. These lipid laden macrophages are even more numerous at the periphery of the infarct. In addition, vascular proliferations and a reactive gliosis surround the infarcted area. Few extravasated erythrocytes can be distinguished.