Histology Course A III 23 Department of Pathology, University of Zurich Histology Course

A III 23 chronic pancreatitis HE further information (German) on HiPaKu 
  ICD-10: K86.0
 
   
55-year-old male was consuming high amounts of alcohol for years. He suffered from pain in the left epigastric region and developed exocrine and endocrine pancreatic insufficiency. Because of excruciating pain pancreatectomy was performed.
 
- Prominent dilatation of several interlobular ducts.
- Lumen of ducts are filled with eosinophilic mucoprotein plugs.
- Ducts mostly lined by flat epithelial cells with a centrally placed nucleus.
- Periductal fibrosis and presence of a chronic inflammatory infiltrate.
- Pancreatic parenchyma with focal slight fibrosis and presence of a chronic inflammatory infiltrate. Fibrosis shows considerable variation and is in the example shown not remarkable.
- Islets are well maintained.

 
Mucoprotein plugs within lumen of dilated ducts often show calcification. Also, squamous metaplasia of duct epithelial cells is frequently seen.