52-year-old female suffered from abnormal vaginal bleeding after sexual intercourse. A Papanicolaou smear revealed the presence of atypical cells. Hysterectomy was performed.
- A continuous intact basal lamina, staining positive for collagen IV, separates the normal epithelium of the portio from the underlying connective tissue.
- Strands or sheets of malignant cells deeply invade the stroma.
- At sites of invasion the basal lamina is fragmented, thinned or completely missing.
- The stroma exhibits de novo formed capillaries and a reactive inflammatory infiltrate.
- Collagen IV positive basal laminas are found subendothelially, around smooth muscle cells, and perineural sheaths.
Compare also slides A III 9 (Carcinoma in situ, CIN III; precancerous lesion), A IV 41 (Carcinoma in situ, CIN III) and A IV 42 (squamous cell carcinoma of the cervix).