Histology Course A III 14 Department of Pathology, University of Zurich Histology Course

A III 14 healed transmural myocardial infarct Sirius further information (German) on HiPaKu 
  ICD-10: I25.2
 
   
72-year-old female succumbed to metastasized carcinoma of the breast (specimen from autopsy).

 
- Large portions of the myocardium are replaced by partly dense fibrous tissue (Sirius-red) consisting of wavy bundles of dense collagen (type I collagen) with presence of only few fibroblasts / fibrocytes (old scar tissue). In some sections of the scar tissue the collagen is less dense and wide capillaries can still be observed.
- The scar tissue is irregularly outlined, entrapping in some parts surviving cardiomyocytes.
- Subendocardial cardiomyocytes are also viable.

 
Compare also slides A II 16, A IV 11