Histology Course A III 11a Department of Pathology, University of Zurich Histology Course

A III 11a osteogenesis imperfecta type II (perinatal-lethal): spinal column HE further information (German) on HiPaKu 
  ICD-10: Q78.0
New born girl (specimen from autopsy).
- A section of the spinal column is shown. Individual vertebral bodies are narrowed and show a markedly thinned and discontinuous corticalis. Trabeculae are reduced in number, irregular and abnormally thin.
- Bone lamellation is increased with individual lamellae being thinner than normal.
- Osteocytes are crowded.
- Multiple organized fractures with fibrosis of the bone marrow are observed.
Clinical findings: Osteogenesis imperfecta type II is uniformly fatal in utero or during the perinatal period. Multiple fractures are acquired while the fetus is still in the womb.